I began my academic career at the Harvard Medical School, where from 1963 to 1965, I was an instructor in the Department of Psychiatry. In 1965, I moved to New York University as associate professor where, together with Alden Spencer and James Schwartz, we developed the first group in the country devoted to both cellular neurobiology and behavior. At the time I was recruited to N.Y.U., Denise was recruited to the Columbia University College of Physicians and Surgeons, where she gradually rose to the rank of professor. In 1974, Harry Grundfest retired and I was recruited to Columbia to replace him. At Columbia I was the founding director of the Center for Neurobiology and Behavior. In 1983, I became a University Professor at Columbia. In 1984, I resigned as director of the Center to become a senior investigator at the newly formed Howard Hughes Medical Research Institute at Columbia. Complete text of Dr. Kandel’s Nobel Prize lecture can be accessed through The Nobel Foundation at http://www.nobel.se/medicine/laureates/2000/kandel-lecture.html For autobiography of Dr. Kandel, click here http://www.nobel.se/medicine/laureates/2000/kandel-autobio.html